ABSTRACT
Objective This study was operated to investigate the association between urinary albumin-to-creatinine ratio (UACR) and physical situations as hypertension and prehypertension among women.Methods Blood pressure,height,weight and waist circumference were measured and factors such as cigarette smoking,alcohol intake,family history of hypertension,were investigated.Blood glucose and lipid,serum uric acid,urinary albumin and urinary creatinine were tested on 1796 women aged ≥30 years living in the Jinchang district of Suzhou.Associations between UACR and hypertension as well as prehypertension were analyzed,by using ordinal multinomial logistic regression models.Results The mean levels of UACR were 15.54 (7.67,32.53),9.01 ( 5.45,18.06),7.13 (4.60,12.50 ) mg/g and the rates of higher UACR were 27.57％,13.42％,9.61％ in hypertensive,pre-hypertensive and normotensive subjects,respectively,with significant differences noticed among the three groups (P＜0.05).The average systolic blood pressure/diastolic blood pressure appeared to be 125.3/80.9,128.8/82.7,130.8/84.0 and 135.1/85.9 mm Hg for participants with UACR in the first,second,third and fourth quartile,respectively.The risks of prehypertension or hypertension increased with increasing UACR levels.Dose-response relationship was seen between UACR and risks of prehypertension or hypertension.Multivariable adjusted odds ratios (95％CI) of prehypertension or hypertension in the upper quartiles of UACR were 1.32 ( 1.02,1.70),1.72 ( 1.32,2.24),and 2.37 (1.80,3.11 ),respectively,when compared with the lowest quartile.Conclusion Elevated UACR was associated with both hypertension and prehypertension among women.
ABSTRACT
Objective To investigate the association betweenserum nitric oxide and microalbuminuria.Methods Based on a community survey in Jinchang district Suzhou city,a 1 ∶ 2 matched case-control study was performed.A total of 208 cases with microalbuminuria were recruited.The controls were selected from the same community,with the same level of income.After matched with age,gender,waist circumference and fast plasma glucose,a total of 416 controls were selected.Values of serum nitric oxide were tested for all eligible participants.The association between serum nitric oxide level and microalbuminuria were analyzed by using the multivariate conditional logistic regression models.Results The mean level of serum nitric oxide was slightly lower for individuals with microalbuminuria (median,interquartile range:27.75,14.48-42.15 μmol/L) than those without (28.25,17.40-43.45 μ mol/L ).However,the difference was not statistically significant (P=0.316).Results from the multivariable conditional logistic regression model showed that serum nitric oxide level was not associated with microalbuminuria,after adjustment for all the confounders.Compared with the highest level of serum nitric oxide,the odds ratios of microalbuminuria for individuals in the 1 st,2nd and 3rd quartiles were not significantly different,after adjustment for confounders.In pairs with hypertension,the odds of microalbuminuria were 85％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.85,95％ CI:0.96-3.57).Additionally,in pairs without hypertension,the odds of microalbuminuria was just 40％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.40,95％CI:0.58-3.40).Conclusion There was no significant correlation between serum nitric oxide and microalbuminuria in the general population in our study.